教育和工作经历:
2012.12 ---
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南京大学物理学院,教授
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2006.12 --- 2012.12
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南京大学物理学院,副教授
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2008. 5 --- 2010. 4
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日本京都大学生物物理系,访问学者(合作导师:Shoji Takada教授)
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2006. 9 --- 2006.11
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南京大学物理系,讲师
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2004. 9 --- 2006. 8
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南京大学物理系,博士后
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1999. 9 --- 2004. 6
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中国科学院近代物理研究所、获理学博士学位
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导师:徐瑚珊教授,张丰收教授,李君清教授
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专业:粒子物理与原子核物理
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论文:基于重离子输运理论对超重核合成及非对称核物质状态方程的研究
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1995. 9 ---- 1999.7
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内蒙古民族大学物理系,获学士学位(物理)
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研究兴趣:
理论与计算生物物理:
1) 多尺度理论和计算方法,及其在生物大分子结构和动力学研究中的应用。
2) 辅助因子(包括金属离子、ATP,
及其它小分子)耦合的蛋白质结构和功能运动的理论和计算机模拟研究。
3) 涨落驱动的生物大分子机器大尺度功能运动。
教学:
承担南京大学本科生“计算物理学”教学工作。
招聘信息:
目前有博士后或专职副研究员职位空缺,年薪18万元以上,主要开展蛋白质分子机器功能动力学
的理论和计算机模拟研究,欢迎有志生物物理研究的博士毕业生应聘。简历投送至:wfli(at)nju.edu.cn
Publication
list(2007 --)
1.
Wenfei Li, Jun Wang, Jian Zhang, Wei Wang
Molecular Simulations of Metal Coupled Protein Folding
Current Opinion in Structural Biology 2015, 30:25-31
2.
Wenfei Li, Wei Wang, and Shoji
Takada
Energy landscape views for interplays among folding,
binding, and allostery of calmodulin domains
Proc. Natl.
Acad. Sci USA 2014, 111:10550-10555
3.
Wenfei Li, Tsuyoshi Terakawa, Wei Wang, and Shoji Takada
Energy landscape and multiroute folding of topologically
complex proteins adenylate kinase and 2ouf-knot
Proc. Natl. Acad. Sci USA 2012, 109:17789-17794
4.
Wenfei Li, Peter G. Wolynes, and Shoji Takada,
Frustration, specific sequence dependence, and nonlinearity
in large-amplitude fluctuations of allosteric proteins,
Proc. Natl. Acad. Sci USA 2011, 108: 3504-3509
5. Wenfei Li and Shoji Takada,
Characterizing protein energy landscape by the self-learning
multiscale simulations: Application to a designed beta-hairpin,
Biophys. J. 2010, 99: 3029-3037.
6. Wenfei Li, Hiroaki Yoshii, Naoto Hori, Tomoshi Kameda,
and Shoji Takada ,
Multiscale methods for protein folding simulations,
Methods 2010, 52: 106-114.
7. Wenfei Li and Shoji Takada,
Self-learning multiscale simulation for achieving high
accuracy and high efficiency simultaneously,
J. Chem. Phys. 2009, 130: 214108.
8. Wenfei Li, Jian Zhang, Jun Wang and Wei Wang,
Metal Coupled folding of Cys2His2 Zinc-finger,
J. Am. Chem. Soc. 2008, 130: 892-900
9. Wenfei Li, Jian Zhang, Yu Su, Jun Wang, Meng Qin, and Wei
Wang,
Effects of Zinc Binding on the Conformational Distribution
of the Amyloid-b Peptide Based on Molecular Dynamics Simulations,
J. Phys. Chem. B. 2007, 111: 13814-13821.
10. Wenfei Li, Jiang Zhang, and Wei Wang
Understanding the Folding and Stability of a Zinc Finger
Based Full Sequence Design Protein with Replica Exchange
Molecular Dynamics Simulations
Proteins 2007, 67: 338-349.
11.
Wenfei Li, Meng Qin, Zuoxiu Tie, and Wei Wang,
Effects of solvents on the intrinsic propensity of peptide backbone
conformations
Phys.Rev.E 2011, 84: 041933
12.
Wenhui Xi, Wenfei Li, and Wei Wang
Template induced conformational change of amyloid-β monomer
J. Phys. Chem. B, 2012, 116: 7398–7405
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